Marseille 2007
| Abstract #19 - High survival rates in HIV infected children living in developing country without widespread access to antiretroviral treatment. | ||||
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Session: 21.7: Vulnerable populations (Parallel) on Monday @ 16.30-18.30 in 5 Chaired by William Fisher, Tomas Campbell Authors: Presenting Author: Mr Emeni Rodrigue Tientcheu - Solidarity Institute of Medical Sciences, Cameroon |
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| Additional Authors: | ||||
| Aim: Information regarding survival rate in children living in developing countries were antiretroviral (ARV) therapy is not available or scares. This study analyzed the overall survival (OS) rate of HIV positive children, without access to ARV, living in Cameroon. | ||||
| Method / Issue: A consecutive sample of 437 HIV positive children followed by the same team of pediatricians between 1999 and 2004 was evaluated. HIV infection in children <18 months of age was calculated using RNA-HIV-1 (Quantiplex b DNA Analyzer, BAYER-CHIRON). Children >18months were considered HIV infected, if blood tested positive for the virus (ELISA, ABBOT). Co-trimoxazole was routinely given to all HIV infected children. Estimated HIV survival rates were obtained by Kaplan Meier method. Multivariate analyses was performed by the Cox model. OS was defined as the time the patient remain alive upto the documented date of death. | ||||
| Results / Comments: 51% of the patients were female and the media OS was 6 years (OS=6,95% CI:5.8,6.9). the rate of survival at 1,5 and 10 years of follow up was 91%, 60% and 22% respectively. Multivariate Cox regression analyses identified 3 significant prognostic factor of mortality; vertical transmissions (RR=2.4, 95% CI:1.4,4.3, p<0.05), mothers death (RR=1.8,95%CI:1.2,2.7,p<0.05),and baseline CD4<250 (RR=1.0,95%CI:1.01,1.05, p<0.05). | ||||
| Discussion: The higher that expected survival rate in this cohort of HIV infected children not taking ARV therapy, and receiving Co-timoxazole, may reflect close medical supervision of clinical symptoms and effective treatments of the most prevalence opportunistic infections in this type of patient. | ||||
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