Barcelona 2013
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| Abstract #88 - Co-infection | ||||
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Session: 8.4: Co-infection (Parallel) on Monday @ 11.00-13.00 in Mirador Chaired by Authors: Presenting Author: mrs caroline lions - ORS PACA- Inserm, France, Metropolitan |
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| Additional Authors: Dr Jordi Casabona, Sra Cristina Sanclemente, Dra Anna Esteve, Dra Victoria Gonzalez, y Grupo HIVITS-TS, | ||||
| Aim: We used longitudinal data from the ANRS CO13 HEPAVIH cohort study to investigate whether polyphenol intake through coffee and/or daily chocolate consumption could play a role in reducing liver enzymes levels. | ||||
| Method / Issue: Longitudinal data collection included self-administered questionnaires and medical data (AST and ALT liver enzymes). Two analyses were performed to assess the association between coffee (>3 cups a day) and daily chocolate intake and abnormal values of AST and ALT (AST or ALT >2.5x upper normal limit (UNL)) (N=990) over time, after adjustment for known correlates. Logistic regression models based on Generalised Estimating Equations were used to take into account the correlations between repeated measures. | ||||
| Results / Comments: Individuals reporting elevated coffee consumption or daily intake of chocolate had a 40-50% reduced risk of abnormal liver enzymes. After multiple adjustments, both associations were confirmed when using abnormal ALT values as the outcome, while only a combined indicator of coffee and chocolate intake remained inversely associated with abnormal AST values. | ||||
| Discussion: Elevated coffee consumption and daily chocolate intake appear to be associated with reduced level of liver enzymes in HIV-HCV co-infected patients. Further experimental and observational research is needed to better understand the role that polyphenol intake or supplementation can play on liver disease and liver injury. | ||||
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