Marseille 2007
Marseille 2007
Abstract book
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Abstract #330  -  Factors associated with health-related quality of life in the context of HIV infection and cancer disease
Session:
  42.5: Wellbeing and quality of life (Parallel) on Tuesday @ 16.30-18.30 in Auditorium/Overflow Chaired by Anna Liguori, Richard Harding
Authors:
  Presenting Author:   Dr PREAU MARIE - INSERM U379 / ORS PACA, France
 
  Additional Authors:   
Aim:
HIV infection and cancer are known to cause significant impairment in patients health-related quality of life (HRQL). The purpose of this study was to compare the patterns of psychosocial and clinical factors associated with HRQL between these two chronic pathologies.
 
Method / Issue:
We used data from two French national cross-sectional surveys: the VESPA-ANRS-EN12 survey (n=2153) which is representative of patients living with HIV and AIDS (PLWHA) in France in 2003, and the ALD-CANCER survey (n=4270) which was conducted in 2004 among French cancer patients two years after HIV positive diagnosis. Psychosocial data, including HRQL assessment using the MOS SF-36 scale, were collected using face-to-face (VESPA) or telephone (ALD-CANCER) interviews of patients. Multivariate logistic regression models were used to identify factors significantly associated with a fair physical (and respectively mental) HRQL, defined as a physical (and respectively mental) composite score (PCS and respectively MCS) above the 25th percentile of the score distribution in the French general population of similar sex and age.
 
Results / Comments:
The percentage of patients presenting a fair physical HRQL was significantly higher among the population of PLWHA than among cancer patients (58% versus 54%,chi-square test: p=0.001), as was the percentage of patients with a fair mental HRQL (70% versus 60%, p<0.0001). Financial difficulties, great discomfort due to treatment-related side effects, and the use of psychoactive drugs were significantly associated with impaired physical and mental HRQL in both contexts. Disclosure of seropositivity was significantly associated with impaired physical and mental HRQL among PLWHA and lung cancer with impaired physical HRQL among cancer patients.
 
Discussion:
In addition to specific factors such as cancer type or patients experience of seropositivity, HIV and cancer disease contexts share several common factors which significantly impair patients HRQL, such as their experience with treatment-related side effects. Close monitoring and suitable management of patients experience with treatments could thus improve their well-being for these two chronic conditions. Besides, disclosure of seropositivity has a negative impact on PLWHAs HRQL. Interventions focused on the acceptance of PLWHA within society are urgently needed.
 
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